Biomarkers, Cell Culture, and Analysis

High throughput screening and liquid handling core

The High Throughput Screening and Liquid Handling (HTS) Core is equipped with advanced automation platforms, including the Echo 650 and Biomek i5 (Beckman), integrated with a centrifuge, temperature controller, and mixer. These systems enable fully automated, high-throughput small molecule screening and liquid handling.

The HTS Core maintains in-house compound libraries comprising:

FDA-approved drugs
Epigenetic modulators
Preclinical compounds
Nucleoside analogs

We support translational research for all USC schools, with a focus on therapeutic development and therapeutic target validation. Our services include: 1) High throughput drug screen, 2) Automated and contactless drug dispensing, 3) High-throughput liquid handling for molecular biology applications; and 4) Assay development and optimization.

Health Sciences Campus
USC Norris Cancer Center
1440 Biggy Street., NOR5838
Los Angeles, CA 90033

Website: https://sites.usc.edu/hts/

USC CIRM ASCEND Shared Resource Laboratory (SRL)

The CIRM ASCEND (Advancing Stem Cell Education and Novel Discoveries) Shared Resource Laboratory (SRL) provides expertise in stem cell and organoid models, coupled with state-of-the-art single cell and spatial sequencing technologies, and linked training courses to the broad California research community. It welcomes students and collaborators from the higher education systems, high school students, and all areas of biotechnology. The CIRM ASCEND SRL is part of a network of SRLs funded by CIRM that are aimed to democratize science by making challenging models, experiments, and tools accessible. For a full set of services provided in California, visit the CIRM website at https://www.cirm.ca.gov.

Eli and Edythe Broad CIRM Center (BCC) for Regenerative Medicine and Stem Cell Research

Keck School of Medicine University of Southern California
1975 Zonal Ave, Los Angeles, CA 90033

Website

Keck Genomic Platform

The Keck Genomics Platform (KGP CORE) provides high-throughput industry-standard next-generation sequencing services to the University of Southern California and its collaborators. KGP utilizes Illumina high-throughput next generation sequencers, such as NovaSeq 6000 and Miseq, to offer comprehensive data analysis, customized pipelines, and secure data management. KGP allows for collaborative research and genomic innovation offering comprehensive services from sample processing to data analysis.

Keck School

1975 Zonal Ave.

Los Angeles, CA 90033

323-442-1100

Website

Agilent Center of Excellence in Biomolecular Characterization

The Agilent Center of Excellence in Biomolecular Characterization was established as a partnership between USC and Agilent technologies with the goal to converge researchers across science and engineering to work together on multidisciplinary approaches for the development of new drugs, diagnostics, and medical devices. The center features first-in-class research instruments ranging from advanced mass spectrometry, chromatography, robotic high-throughput reaction screening, genomics, and optical characterization.

Located at Michelson since 2018

Website

The Research Center for Liver Disease Cell and Tissue Imaging Core

The USC Research Center for Liver Diseases (RCLD) was originally founded in March 1995 and has been continuously funded by a grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK P30 DK048522) for four consecutive 5-year cycles through 2/21. Dr. Neil Kaplowitz is the interim Director.

Keck School

1975 Zonal Ave.

Los Angeles, CA 90033

Website

The Research Center for Liver Disease Liver Histology(LH) Core

The Liver Histology Core provides basic histology services to the members of the Research Center for Liver Disease members. We do processing, sectioning and staining for animal tissues of formalin fixed specimens, which need to be submitted in 70% alcohol. (We can do processing and embedding of such tissues for nonmember investigators, but not sectioning.) We also provide frozen sectioning of animal tissue for our members only.

Keck School

1975 Zonal Ave.

Los Angeles, CA 90033

Website