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You are here: Home / Archives for Biomarkers, Cell Culture, and Analysis

Biomarkers, Cell Culture, and Analysis

Translational Research Laboratory

The core mission of the USC Mann School of Pharmacy Translational Research Laboratory (TRLab), located in 13laboratory spaces of the Pharmaceutical Sciences Center, has been to provide investigators with a state-of-the-art technological platform and technical expertise to advance translational research endeavors in the Mann School of Pharmacy and at USC.

Equipment and services include: The TRLab is equipped with over 80 specialized instruments in the applications of: 1) Sample Processing, 2) Cell and Immunobiology, 3) Flow Cytometry, 4) Imaging, 5) Molecular Analysis, 6) Molecular Biology and 7) RNA/DNA Sequencing.

Health Sciences Campus
Pharmaceutical Sciences Center
Website

Circulating Tumor Cells Research Core

Circulating tumor cells (CTCs) are cancer cells shed by solid tumors into the bloodstream. CTCs have recently emerged as valuable prognostic and predictive cancer biomarkers, providing a non-invasive window into disease biology and progression that can be sampled repeatedly over time from a simple blood draw. Moreover, CTC sampling enables real time tracking of cancer plasticity as tumor cells evolve over time and through progressive lines of therapy, thus elucidating mechanisms of cancer dissemination and identifying new therapeutic targets. As such, CTC characterization holds the promise of enabling real-time molecular phenotyping of individual cancer patients’ tumors at diagnosis and throughout treatment, advancing precision medicine in this important and vast patient group. The USC Norris CTC Research Core is a state-of-the-art, multi-platform facility for the capture and analysis of peripheral blood CTCs. The Core employs a variety of technologies that enrich CTCs for enumeration or molecular characterization. Enrichment is done from blood samples drawn by standard venous puncture from patients. In addition, Dr. Goldkorn’s team has developed mouse xenograft research models using labeled CTCs that can be recovered from the mice.

Health Sciences Campus
USC Norris Cancer Center
1450 Biggy Street., NRT6516
Los Angeles, CA 90033
Contact Information

Chang Stem Cell Engineering Facility

The Chang Stem Cell Engineering Facility genetically modifies embryonic stem (ES) cells and induced pluripotent stem (iPS) cell lines. Genetically modified ES and iPS cell lines derived from disease-specific animal models and patients provide an opportunity to investigate the mechanisms of disease and to further develop new treatments for clinical therapy. 

Services include: genome editing, iPS cell derivation, and ES cell derivation.

Health Sciences Campus
Eli and Edythe Broad CIRM Center
1425 San Pablo Street, BCC 205
Los Angeles, CA 90033
Website

Bioreagent and Cell Culture Core

The Bioreagent and Cell Culture Core supports cancer related research that requires in vitro experiments, provides reagents for cell culture and prepares bioreagents that are produced by cells grown in the Core. It is one of the longest standing and most widely used shared resources of the Cancer Center.

USC Norris Comprehensive Cancer Center
1441 Eastlake Ave
NOR5323
Los Angeles CA 90033
Website

Seahorse Core Facility Gerontology

About the Seahorse XF96 Analyzer: The Seahorse XF96 is a unique instrument that measure extracellular O2, pH, glucose and lactate fluxes to provide estimates of glucose utilization in cultured cells. The XF96 instrument provides a significant advance over existing methodologies to quantitate cellular metabolic pathways. Unlike radiometric assays, the XF96 does not require radiolabeled substrates, and unlike measurements of cellular oxygen consumption using the classic Clark electrode, it is possible to make high throughput measurements on 96 samples simultaneously in a microplate format.

Davis School of Gerontology
3715 McClintok Ave, B1A
Los Angeles, CA 90089
Website

Aging Biomarker and Service Core

Aging Biomarker and Service Core owns QuickPlex SQ 120 (Meso Scale Discovery, MSD) and SpectraMax M3 multi-mode microplate readers (Molecular Device).

The ELISA services include: 1) cytokines measurement, 2) Alzheimer-related markers (Amyloid beta, phospho-tau) measurement, 3) hormones measurement including GH, human and mouse IGF-I& IGFBPs, etc., 4) metabolic biomarkers measurement including insulin, leptin and adiponectin, 5) mitochondrial derived peptides (MDPs) measurement including humanin and the other novel MDPs, 6) new assay development.

University Park Campus
3715 McClintock Ave.
Davis School of Gerontology
GER #B1B
Los Angeles, CA 90089
Website

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