Animal Resources

Animal Core

The Animal Core is the center’s scientific hub for catalyzing research on in vivo genetic analysis and synergism between alcohol and risk factors for the pathogenesis of alcoholic liver and pancreatic diseases (ALPD) by investigators within and outside of the center.

Models Provided by the Animal Core: Mouse iG-Std Model, Mouse iG-OF (overfeeding) produces synergistic steatohepatitis by alcohol and obesity, Hybrid HCFD+Alc Model, Hybrid HCFD+Alc+Binge Model, and Rat iG-Std,

1975 Zonal Ave, Los Angeles, CA 90033

323-442-1100

Website

Functional Biological Imaging Core

The Functional Biological Imaging Center is a newly formed pre-clinical imaging resource at the Zilkha Neurogenetic Institute takes advantage of state-of-the-art preclinical MRI/PET instrumentation provided by MR Solutions (Guildford UK). Simultaneous acquisition of PET and MR images is a newly emerging technology that marries the exquisite sensitivity of PET with the high spatial resolution and soft tissue contrast of MRI.

1975 Zonal Ave.
Los Angeles, CA 90033

Website

Transgenic/ Knockout Rodent Core Facility

The USC Norris Comprehensive Cancer Center Transgenic/Knockout Core Facility provides high-quality embryo and stem cell manipulation, microinjection and related services to the USC community, as well as non-USC researchers. Services include: gene targeting and the production of knockout rats and mice, transgenic mice, construction targeting vector design, preparation of DNA for injection and in vitro fertilization, re-derivation, and cryopreservation.

Health Sciences Campus
USC Norris Comprehensive Cancer Center
1441 Eastlake Ave. Room 5318
Los Angeles, CA 90089-9176
Website

Molecular Imaging Center – Small Animal Imaging

The USC Molecular Imaging Center focuses on the translational needs of investigators to allow in vivo imaging of disease processes and development of new molecular therapeutics and diagnostics, providing support to research studies of small animals for a variety of applications. Equipment and services include: training and/or assistance with study design, imaging procedures, imaging probe design, and image analysis are provided in the use of microCT, microPET, micro-ultrasound, optical imaging, radio chemistry as well as radiography and autoradiography systems.

Health Sciences Campus
Clinical Science Center
2250 Alcazar Street, CSC/IGM 103
Los Angeles, CA 90033-9061
Website

Integrative Liver Cell Core

The Research Center For Alcoholic Liver and Pancreatic Disease core laboratories supports center investigators and serves as a national resource. Animal Core services include: mouse intragastric (iG) and ad lib ethanol feeding models which produce clinically relevant pathologic spectra of ALPD; routine BAL and ALT measurements; non-parenchymal liver cell core services, terminal experiments and sample collection, as well as a Tissue Sharing and Training Program. Animal models include: Rodent iG Models Standard iG model; Hybrid model of Western Diet ad lib and Alcohol iG feeding for ASH with liver fibrosis; Hybrid plus Binge Model of Alcoholic Hepatitis and Alcohol/HCV Liver Tumor Models: Metabolomics Core services include: metabolomics analysis in animals and isolated cells, such as stable isotope-based (13C and 2H).

Health Sciences Campus
Mudd Memorial Research Building
1333 San Pablo Street, MMR 412
Los Angeles, CA
Website

Department of Animal Resources

The Department of Animal Resources and the Institutional Animal Care and Use Committee assist faculty in preparing proposals and carrying out animal-based research and teaching activities at USC.

Services include: clinical, surgical and diagnostic laboratory services, ordering drugs and supplies, animal orders and transfers and rodent euthanasia. Training programs in Animal Care and Use are also offered to principal investigators, staff and students, as well as education programs for Laboratory Animal Technicians.

Health Sciences Campus
Center for Health Professions 234
University of Southern California
Los Angeles, CA 90033-9004
Website