Structural Biology

John O’Brien Nanofabrication Laboratory

The vision behind the design of the John O’Brien Nanofabrication Laboratory is to move beyond conventional silicon processing. The breadth of instrumentation enables the core to support diverse research activities, from fundamental quantum transport studies to nano/bioconvergent research. Enabling interdisciplinary research with next generation nanomaterials is a strong focus of the facility. This emphasis is unique among nanofabrication facilities and enables researchers to translate novel materials into transformational devices for a wide range of applications.

Located at Michelson since 2021

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The Research Center for Liver Disease Cell Separation and Culture(CSC) core

The combined Cell Separation and Culture Core provides two major types of services: 1) cell separation to allow functional analysis of different cell types; and 2) isolation and culture of primary hepatocytes from normal and diseased rodents. Some of the additional services they provide include: 1) 4-8 parameter flow cytometric analyses by BD FACSCalibur and BD FACSVerse cell analyzers; 2) Positive or negative cell separation by Miltenyi AutoMACS Pro instrument. This Core is only open to the Research Center for Liver Disease members.

Keck School

1975 Zonal Ave.

Los Angeles, CA 90033

323-442-1100

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Translational Research in Vivo Core

Welcome to the Translational Research In Vivo Core Facility, a center dedicated to state-of-the-art research. The facility has more than 12,000 sq. ft. and includes dedicated procedure rooms. Two full-time technicians are available to assist researchers with procedures and equipment operation. A third technician is available to process tissue for histological analysis.

SC Ginsburg Institute for Biomedical Therapeutics

Keck School of Medicine University of Southern California
1450 San Pablo Street, Room 6500

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X-Ray Crystallography Facility

The purpose of the X-Ray Crystallography Facility is to structurally characterize single-crystal samples of organic, inorganic, and organometallic compounds using X-ray diffraction. Equipment and services include: a Bruker APEX DUO single-crystal diffractometer equipped with an APEX2 CCD detector, Mo fine-focus and Cu micro-focus X-ray sources and a Rigaku Ultima IV powder/thin film diffractometer to conduct rapid structural analysis. It is capable of handling samples that are sensitive to air, moisture, and/or temperature and the core provides training for users to conduct their own experiments.

University Park Campus
John Stauffer Science Lecture
837 Bloom Walk
Los Angeles, CA 90087

Structural Biology Center

Structural Biology Center @ Bridge (SBC@Bridge) would provide you all the necessary means required for structural determination of your protein of interest either soluble or membrane protein. Here at SBCB you have access to a world class facility and highly trained experts to assist you to achieve your goal.

SBC@Bridge can assist you in sample preparation, protein characterization, ligand search, crystallization, data collection and structural determination of your protein.

University Park Campus
3430 S Vermont Ave
Los Angeles, CA 90089
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USC Center of Excellence for Molecular Characterization

The Department of Chemistry operates a Nuclear Magnetic Resonance Spectroscopy lab for the investigation of magnetic properties of nuclei, providing information on the number and type of chemical entities in molecules. Equipment includes: NMR spectrometers, a Quantum Technologies Helium Liquifier as well as additional equipment available at their X-Ray Crystallographic facility. The Center also provides access to analytical software and computational workstations, including Varian VNMRJ for Red Hat Linux, Mestrelab MestReNova (all platforms) and Chemistry data archival services.

University Park Campus
Laird J. Stable Memorial Hall
840 Downey Way, LJS 159
Los Angeles, CA 90033
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