Histology and Pathology

Translational Research Laboratory

The core mission of the USC Mann School of Pharmacy Translational Research Laboratory (TRLab), located in 13laboratory spaces of the Pharmaceutical Sciences Center, has been to provide investigators with a state-of-the-art technological platform and technical expertise to advance translational research endeavors in the Mann School of Pharmacy and at USC.

Equipment and services include: The TRLab is equipped with over 80 specialized instruments in the applications of: 1) Sample Processing, 2) Cell and Immunobiology, 3) Flow Cytometry, 4) Imaging, 5) Molecular Analysis, 6) Molecular Biology and 7) RNA/DNA Sequencing.

Health Sciences Campus
Pharmaceutical Sciences Center
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Translational Pathology Facility – Adult Tissue Arm

The Translational Pathology Core Facility – Adult Tissue Arm provides a single point of access for tissue procurement and banking services for funded HSC and UPC investigators. We procure, bank, process, track and distribute both fresh/frozen and formalin-fixed paraffin embedded normal and pathologic human tissue biospecimens for investigators with IRB approved studies. We also provide histology services for both human biospecimens and animal tissues, including embedding, sectioning, and histologic staining and design and construction of tissue microarrays to support translational and basic research studies and we process blood/fluid specimens for translational research studies.

Health Sciences Campus
Norris Comprehensive Cancer Center
1441 Eastlake Ave.
Los Angeles, CA 90089
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Integrative Liver Cell Core

The Research Center For Alcoholic Liver and Pancreatic Disease core laboratories supports center investigators and serves as a national resource. Animal Core services include: mouse intragastric (iG) and ad lib ethanol feeding models which produce clinically relevant pathologic spectra of ALPD; routine BAL and ALT measurements; non-parenchymal liver cell core services, terminal experiments and sample collection, as well as a Tissue Sharing and Training Program. Animal models include: Rodent iG Models Standard iG model; Hybrid model of Western Diet ad lib and Alcohol iG feeding for ASH with liver fibrosis; Hybrid plus Binge Model of Alcoholic Hepatitis and Alcohol/HCV Liver Tumor Models: Metabolomics Core services include: metabolomics analysis in animals and isolated cells, such as stable isotope-based (13C and 2H).

Health Sciences Campus
Mudd Memorial Research Building
1333 San Pablo Street, MMR 412
Los Angeles, CA
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Histology Laboratory

Histology Laboratory provides histology services for any types of tissues: tissue processing, embedding, sectioning colorimetric dye staining (e.g. H&E) and imaging. Expert advice is available concerning staining techniques and the interpretation of microscopic images. The cryostat and microtome are also available for use by reservation only.

Equipment and services include: Microm Spin Tissue Processor STP 120, Microm Tissue Embedding Center EC350, Microm Rotary Microtome HM310, Vibratome, Microm Cryostat HM 525, CryoJane, Thermo Shandon Hyperclean Station, microscopes and HTS imaging system.

Health Sciences Campus
Pharmaceutical Sciences Center (PSC B6)