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Compound Testing and High-Throughput Analysis

High throughput screening and liquid handling core

The High Throughput Screening and Liquid Handling (HTS) Core is equipped with advanced automation platforms, including the Echo 650 and Biomek i5 (Beckman), integrated with a centrifuge, temperature controller, and mixer. These systems enable fully automated, high-throughput small molecule screening and liquid handling.

The HTS Core maintains in-house compound libraries comprising:

  1. FDA-approved drugs
  2. Epigenetic modulators
  3. Preclinical compounds
  4. Nucleoside analogs

We support translational research for all USC schools, with a focus on therapeutic development and therapeutic target validation. Our services include: 1) High throughput drug screen, 2) Automated and contactless drug dispensing, 3) High-throughput liquid handling for molecular biology applications; and 4) Assay development and optimization.

Health Sciences Campus
USC Norris Cancer Center
1440 Biggy Street., NOR5838
Los Angeles, CA 90033

Website:  https://sites.usc.edu/hts/

Keck Genomic Platform

The Keck Genomics Platform (KGP CORE) provides high-throughput industry-standard next-generation sequencing services to the University of Southern California and its collaborators. KGP utilizes Illumina high-throughput next generation sequencers, such as NovaSeq 6000 and Miseq, to offer comprehensive data analysis, customized pipelines, and secure data management. KGP allows for collaborative research and genomic innovation offering comprehensive services from sample processing to data analysis.

Keck School

1975 Zonal Ave.

Los Angeles, CA 90033

323-442-1100

Website

The Research Center for Liver Disease Cell and Tissue Imaging Core

The USC Research Center for Liver Diseases (RCLD) was originally founded in March 1995 and has been continuously funded by a grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK P30 DK048522) for four consecutive 5-year cycles through 2/21. Dr. Neil Kaplowitz is the interim Director.

Keck School

1975 Zonal Ave.

Los Angeles, CA 90033


Website

Seahorse Core Facility Gerontology

About the Seahorse XF96 Analyzer: The Seahorse XF96 is a unique instrument that measure extracellular O2, pH, glucose and lactate fluxes to provide estimates of glucose utilization in cultured cells. The XF96 instrument provides a significant advance over existing methodologies to quantitate cellular metabolic pathways. Unlike radiometric assays, the XF96 does not require radiolabeled substrates, and unlike measurements of cellular oxygen consumption using the classic Clark electrode, it is possible to make high throughput measurements on 96 samples simultaneously in a microplate format.

Davis School of Gerontology
3715 McClintok Ave, B1A
Los Angeles, CA 90089
Website