Internal Deadline: Monday, December 18, 2023, 5pm PT
LOI: February 13, 2024
External Deadline: March 13, 2024
Award Type: Cooperative Agreement
Estimated Number of Awards: 16
Anticipated Award Amount: Application budgets are limited to $500,000 per year in direct costs. Facilities and administrative costs requested by consortium participants are not included in the direct cost limitation.
Who May Serve as PI: Standard NIH requirements.
Process for Limited Submissions
PIs must submit their application as a Limited Submission through the Research Initiatives and Infrastructure (RII) Application Portal: https://rii.usc.edu/oor-portal/. Use the template provided here: RII Limited Submission Applicant Template
Materials to submit include:
- (1) Two-Page Proposal Summary (1” margins; single-spaced; standard font type, e.g. Arial, Helvetica, Times New Roman, or Georgia typeface; font size: 11 pt). Page limit includes references and illustrations. Pages that exceed the 2-page limit will be excluded from review. You must use the template linked above.
- (2) CV – (5 pages maximum)
Note: The portal requires information about the PIs in addition to department and contact information, including the 10-digit USC ID#, Gender, and Ethnicity. Please have this material prepared before beginning this application.
This notice of funding opportunity (NOFO) invites applications from clinical investigators to participate in the National Drug Abuse Treatment Clinical Trials Network (CTN). The National Institute on Drug Abuse (NIDA) intends to continue to develop and test interventions to address a variety of substance use problems via collaborative partnerships among NIDA, clinical research investigators, community representatives, healthcare providers, and healthcare institutions.
The CTN was established in 1999 to bridge the gap between research and practice to improve substance use disorder (SUD) treatment. Through the collaborative partnership of researchers, treatment providers, and other community members, the CTN seeks to address critical research questions with direct relevance to clinical practice and the needs of people with SUDs. CTN research includes efficacy, effectiveness, and implementation research conducted primarily through multi-site clinical trials. Over the last two decades, the CTN’s research infrastructure and agenda have evolved to reflect the changing landscape of the SUD treatment community, transformation of health care systems, and emerging scientific advancements.
The CTN currently is comprised of 16 Nodes, a Data and Statistics Center (DSC), and a Clinical Coordinating Center (CCC). Each Node is a primary performance site, with numerous affiliated clinical research sites. The CTN program is administered within NIDA through the Center for the Clinical Trials Network (CCTN). NIDA plans to continue supporting the CTN research infrastructure to build on the broad portfolio of research conducted in the CTN. Applications proposing new Nodes and renewals of existing Nodes are encouraged. Applications proposing Multiple Principal Investigator (MPI) collaborations to form regional consortia are especially encouraged. NIDA has an interest in extending the reach of the CTN to regions of the country that are heavily impacted by substance use and not currently represented in the Network.
Inclusion of core faculty and MPI from diverse backgrounds, including individuals from underrepresented groups in biomedical research is encouraged. NIH and NIDA support the formation of research teams that represent diverse perspectives, backgrounds (see NOT-OD-20-031 and NOT-OD-22-019), and academic and technical disciplines, as well as the submission of research applications from all eligible institutions. Applications from researchers from diverse backgrounds, including individuals from underrepresented groups across roles and positions in research are strongly encouraged to apply to this NOFO.
Objectives of Nodes
- Develop and conduct clinical trials to evaluate SUD prevention, treatment, recovery, and implementation interventions.
- Engage and actively involve community partners including people with lived experience to inform needs and benefit the health of participants and ensure health equity and inclusion principles are a fundamental aspect of research.
- Ensure that CTN SUD research encompasses youth and individuals from NIH-designated U.S. health disparity populations including American Indians/Alaska Natives, Asian Americans, Blacks/African Americans, Hispanics/Latinos, Native Hawaiians and other Pacific Islanders, sexual and gender minorities, socioeconomically disadvantaged populations, underserved rural populations, and people with disabilities.
- Develop collaborations with organizations where patients are located such as pharmacy systems and community groups and settings.
- Generate evidence that addresses sustainability and informs healthcare policy decisions and clinical guidelines in healthcare settings.
- Translate and disseminate research findings to the public, clinicians, and policymakers.
Visit our Institutionally Limited Submission webpage for more updates and other announcements.